Effect of stenosis shape on the sound emitted from a constricted blood vessel

Ozden K., SERT C., YAZICIOĞLU Y.

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, vol.58, no.3, pp.643-658, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.1007/s11517-020-02119-7
  • Journal Name: MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, ABI/INFORM, Agricultural & Environmental Science Database, Applied Science & Technology Source, BIOSIS, Biotechnology Research Abstracts, Business Source Elite, Business Source Premier, CINAHL, Compendex, Computer & Applied Sciences, EMBASE, INSPEC, MEDLINE
  • Page Numbers: pp.643-658
  • Keywords: Blood flow, Atherosclerosis, Stenosis shape, Sound emission, Large eddy simulation, CORONARY-ARTERY-DISEASE, DIRECT NUMERICAL-SIMULATION, NON-NEWTONIAN VISCOSITY, LARGE-EDDY SIMULATION, PULSATILE FLOW, TURBULENT-FLOW, CAROTID STENOSIS, FLUID, FIELD, TUBE
  • Middle East Technical University Affiliated: Yes

Abstract

Effect of stenosis shape on the post-stenotic pressure fluctuations and the sound emitted from a constricted blood vessel is studied numerically. Large eddy simulations are performed using OpenFOAM under pulsatile flow conditions with a non-Newtonian fluid model. Findings indicate that the high slope at the stenosis entrance and overlap of more than one stenosis shorten the length of the flow jet, trigger turbulence, and increase vortical activity, turbulent kinetic energy, and magnitude of pressure fluctuations at the post-stenotic region. Also, these morphological parameters strengthen the audible signal especially in the systolic phase of the pulsatile flow. On the other hand, asymmetry of the stenosis creates an opposite effect. Based on the wall pressure data, it is shown that the stenosis shape affects the intensity and the pattern of the murmurs generated. Stenosis shape is found to be an essential factor for the acoustic-based non-invasive diagnosis of stenosis.