Effect of stenosis shape on the sound emitted from a constricted blood vessel

Ozden K., SERT C., YAZICIOĞLU Y.

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, cilt.58, sa.3, ss.643-658, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s11517-020-02119-7
  • Dergi Adı: MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, ABI/INFORM, Agricultural & Environmental Science Database, Applied Science & Technology Source, BIOSIS, Biotechnology Research Abstracts, Business Source Elite, Business Source Premier, CINAHL, Compendex, Computer & Applied Sciences, EMBASE, INSPEC, MEDLINE
  • Sayfa Sayıları: ss.643-658
  • Anahtar Kelimeler: Blood flow, Atherosclerosis, Stenosis shape, Sound emission, Large eddy simulation, CORONARY-ARTERY-DISEASE, DIRECT NUMERICAL-SIMULATION, NON-NEWTONIAN VISCOSITY, LARGE-EDDY SIMULATION, PULSATILE FLOW, TURBULENT-FLOW, CAROTID STENOSIS, FLUID, FIELD, TUBE
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Effect of stenosis shape on the post-stenotic pressure fluctuations and the sound emitted from a constricted blood vessel is studied numerically. Large eddy simulations are performed using OpenFOAM under pulsatile flow conditions with a non-Newtonian fluid model. Findings indicate that the high slope at the stenosis entrance and overlap of more than one stenosis shorten the length of the flow jet, trigger turbulence, and increase vortical activity, turbulent kinetic energy, and magnitude of pressure fluctuations at the post-stenotic region. Also, these morphological parameters strengthen the audible signal especially in the systolic phase of the pulsatile flow. On the other hand, asymmetry of the stenosis creates an opposite effect. Based on the wall pressure data, it is shown that the stenosis shape affects the intensity and the pattern of the murmurs generated. Stenosis shape is found to be an essential factor for the acoustic-based non-invasive diagnosis of stenosis.