Automated Parallel Dialysis for Purification of Polymers

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Terzioglu I., Ventura-Hunter C., Ulbrich J., Saldivar-Guerra E., Schubert U. S., Guerrero-Sanchez C.

POLYMERS, vol.14, no.22, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 22
  • Publication Date: 2022
  • Doi Number: 10.3390/polym14224835
  • Journal Name: POLYMERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Communication Abstracts, Compendex, Food Science & Technology Abstracts, INSPEC, Metadex, Directory of Open Access Journals, Civil Engineering Abstracts
  • Keywords: polymer libraries, purification, automation, dialysis, high-throughput, -output experimentation, LOADED POLY(LACTIDE-CO-GLYCOLIDE) MICROSPHERES, RESIDUAL MONOMER, RELEASE, COPOLYMERS, SOLVENTS, BEHAVIOR, PURITY
  • Middle East Technical University Affiliated: No

Abstract

The implementation of a dialysis method for the simultaneous purification of different polymer materials in a commercially available automated parallel synthesizer (APS) is discussed. The efficiency of this "unattended" automated parallel dialysis (APD) method was investigated by means of proton nuclear magnetic resonance (H-1-NMR) measurements, which confirmed that the method enables the removal of up to 99% of the unreacted monomer derived from the synthesis of the corresponding polymers in the APS. Size-exclusion chromatography (SEC) revealed that the molar mass and molar mass distribution of the investigated polymers did not undergo significant changes after the application of the APD method. The method discussed herein can be regarded as a good alternative to the "unattended" and reliable purification of polymer libraries prepared in APS. This method may be useful for overcoming current limitations of high-throughput/-output (HT/O) synthesis of polymer libraries, where purification of the generated materials currently represents a significant constraint for establishing fully automated experimental workflows necessary to advance towards a full digitalization of research and development of new polymers for diverse applications.