Modeling of reaction-diffusion transport into a core-shell geometry


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King C. C. , Brown A. A. , Sargin I., Bratlie K. M. , Beckman S. P.

JOURNAL OF THEORETICAL BIOLOGY, vol.460, pp.204-208, 2019 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 460
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jtbi.2018.09.026
  • Journal Name: JOURNAL OF THEORETICAL BIOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.204-208

Abstract

Fickian diffusion into a core-shell geometry is modeled. The interior core mimics pancreatic Langerhan islets and the exterior shell acts as inert protection. The consumption of oxygen diffusing into the cells is approximated using Michaelis-Menten kinetics. The problem is transformed to dimensionless units and solved numerically. Two regimes are identified, one that is diffusion limited and the other consumption limited. A regression is fit that describes the concentration at the center of the cells as a function of the relevant physical parameters. It is determined that, in a cell culture environment, the cells will remain viable as long as the islet has a radius of around 142 mu m or less and the encapsulating shell has a radius of less than approximately 283 mu m. When the islet is on the order of 100 mu m it is possible for the cells to remain viable in environments with as little as 4.6 x 10(-2) mol/m(-3) O-2. These results indicate such an encapsulation scheme may be used to prepare artificial pancreas to treat diabetes. (C) 2018 Elsevier Ltd. All rights reserved.