Conversion of homochiral amines, beta-amino alcohols and alpha-amino acids to their chiral 2-substituted pyrrole derivatives

Demir A., Akhmedov I., Sesenoglu O., Alpturk O., Apaydin S., Gercek Z., ...More

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, no.10, pp.1162-1167, 2001 (SCI-Expanded) identifier identifier


The conversion of the amino group of chiral amines, amino alcohols, amino acids and their esters into chiral 2-substituted pyrrole derivatives with various halogeno enones is described. The conversion works in good yield and without racemization. The synthesis of 2-phenylpyrrole derivatives was possible with amino alcohols but not with amino acids or their esters.