Conversion of homochiral amines, beta-amino alcohols and alpha-amino acids to their chiral 2-substituted pyrrole derivatives

Demir, AYHAN; Akhmedov, IM; Sesenoglu, O; Alpturk, O; Apaydin, S; Gercek, Z; Ibrahimzade, N

doi:10.1039/b008317h

Conversion of homochiral amines, beta-amino alcohols and alpha-amino acids to their chiral 2-substituted pyrrole derivatives

Demir A., Akhmedov I., Sesenoglu O., Alpturk O., Apaydin S., Gercek Z., ...More

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, no.10, pp.1162-1167, 2001 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Publication Date: 2001
Doi Number: 10.1039/b008317h
Journal Name: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1162-1167
Middle East Technical University Affiliated: Yes

Abstract

The conversion of the amino group of chiral amines, amino alcohols, amino acids and their esters into chiral 2-substituted pyrrole derivatives with various halogeno enones is described. The conversion works in good yield and without racemization. The synthesis of 2-phenylpyrrole derivatives was possible with amino alcohols but not with amino acids or their esters.