Amination/annulation of chlorobutenones with chiral amine compounds: synthesis of 1,2,4-trisubstituted pyrroles


Demir A. , Igdir A., Gunay N.

TETRAHEDRON-ASYMMETRY, cilt.16, ss.3170-3175, 2005 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 16 Konu: 19
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.tetasy.2005.08.033
  • Dergi Adı: TETRAHEDRON-ASYMMETRY
  • Sayfa Sayıları: ss.3170-3175

Özet

A series of 1,2,4-trisubstituted pyrroles have been synthesized in 83-96% yields on treatment of chiral primary amines, amino alcohols and esters of alpha-amino acids with different chlorobutenones in benzene-triethylamine. The conversions proceed without racemization. (c) 2005 Elsevier Ltd. All rights reserved.