Amination/annulation of chlorobutenones with chiral amine compounds: synthesis of 1,2,4-trisubstituted pyrroles
TETRAHEDRON-ASYMMETRY, vol.16, no.19, pp.3170-3175, 2005 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 16 Issue: 19
- Publication Date: 2005
- Doi Number: 10.1016/j.tetasy.2005.08.033
- Journal Name: TETRAHEDRON-ASYMMETRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.3170-3175
- Middle East Technical University Affiliated: Yes
Abstract
A series of 1,2,4-trisubstituted pyrroles have been synthesized in 83-96% yields on treatment of chiral primary amines, amino alcohols and esters of alpha-amino acids with different chlorobutenones in benzene-triethylamine. The conversions proceed without racemization. (c) 2005 Elsevier Ltd. All rights reserved.