Amination/annulation of chlorobutenones with chiral amine compounds: synthesis of 1,2,4-trisubstituted pyrroles


Demir A. , Igdir A., Gunay N.

TETRAHEDRON-ASYMMETRY, vol.16, no.19, pp.3170-3175, 2005 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 19
  • Publication Date: 2005
  • Doi Number: 10.1016/j.tetasy.2005.08.033
  • Title of Journal : TETRAHEDRON-ASYMMETRY
  • Page Numbers: pp.3170-3175

Abstract

A series of 1,2,4-trisubstituted pyrroles have been synthesized in 83-96% yields on treatment of chiral primary amines, amino alcohols and esters of alpha-amino acids with different chlorobutenones in benzene-triethylamine. The conversions proceed without racemization. (c) 2005 Elsevier Ltd. All rights reserved.