Crosstalk Between Phase-Separated Membraneless Condensates and Membrane-Bound Organelles in Cellular Function and Disease
Advances in experimental medicine and biology, cilt.1483, ss.141-169, 2025 (Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 1483
- Basım Tarihi: 2025
- Doi Numarası: 10.1007/5584_2025_852
- Dergi Adı: Advances in experimental medicine and biology
- Derginin Tarandığı İndeksler: Scopus, EMBASE
- Sayfa Sayıları: ss.141-169
- Anahtar Kelimeler: Cancer, Cardiovascular diseases, Condensate, Liquid-liquid phase separation, Membraneless granules, Neurodegenerative diseases, Organelle
- Orta Doğu Teknik Üniversitesi Adresli: Evet
Özet
Compartmentalization in eukaryotic cells allows the spatiotemporal regulation of biochemical processes, in addition to allowing specific sets of proteins to interact in a regulated as well as stochastic manner. Although membrane-bound organelles are thought to be the key players of cellular compartmentalization, membraneless biomolecular condensates such as stress granules, P bodies, and many others have recently emerged as key players that are also thought to bring order to a highly chaotic environment. Here, we have evaluated the latest studies on biomolecular condensates, specifically focusing on how they interact with membrane-bound organelles and modulate each other's functions. We also highlight the importance of this interaction in neurodegenerative and cardiovascular diseases as well as in cancer.