Mismatch between obesogenic intrauterine environment and low-fat postnatal diet may confer offspring metabolic advantage
OBESITY SCIENCE & PRACTICE, cilt.7, sa.4, ss.450-461, 2021 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 7 Sayı: 4
- Basım Tarihi: 2021
- Doi Numarası: 10.1002/osp4.501
- Dergi Adı: OBESITY SCIENCE & PRACTICE
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, Directory of Open Access Journals
- Sayfa Sayıları: ss.450-461
- Anahtar Kelimeler: fetal programming, glucose tolerance, insulin resistance, maternal obesity
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Orta Doğu Teknik Üniversitesi Adresli: Evet
Özet
Objective: Mismatch between a depleted intrauterine environment and a substrate-rich postnatal environment confers an increased risk of offspring obesity and metabolic syndrome. Maternal diet-induced obesity (MATOB) is associated with the same outcomes. These experiments tested the hypothesis that a mismatch between a nutrient-rich intrauterine environment and a low-fat postnatal environment would ameliorate offspring metabolic morbidity.