A simple synthesis of 1-aminophosphonic acids from 1-hydroxyiminophosphonates with NaBH4 in the presence of transition metal compounds


Demir A. , Tanyeli C. , Sesenoglu O., Demic S., Evin O.

TETRAHEDRON LETTERS, cilt.37, ss.407-410, 1996 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 37 Konu: 3
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1016/0040-4039(95)02171-x
  • Dergi Adı: TETRAHEDRON LETTERS
  • Sayfa Sayıları: ss.407-410

Özet

A new procedure has been developed for the synthesis of 1-aminophosphonic acids. Diethyl phosphonates are converted to hydroxyiminophosphonates when treated with hydroxylamine hydrochloride. Reduction of hydroxyiminophosphonates with NaBH4 in MeOH in the presence of MoO3 or NiCl2 and hydrolysis of 1- aminophosphonates gave 1-aminophosphonic acids in good yield.