Enantioselective direct aldol reactions promoted by phosphine oxide aziridinyl phosphonate organocatalysts


DOĞAN Ö., TAN D.

TETRAHEDRON-ASYMMETRY, cilt.26, sa.23, ss.1348-1353, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 23
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.tetasy.2015.10.013
  • Dergi Adı: TETRAHEDRON-ASYMMETRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1348-1353
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

A series of phosphine oxide based chiral Lewis bases were screened as organocatalysts for silicon tetrachloride mediated direct asymmetric aldol reactions between cyclohexanone and various aromatic aldehydes. One of the phosphine oxide-aziridinyl phosphonate POAP-A Lewis bases formed the aldol products in up to 75% yield and with 65% ee. (C) 2015 Elsevier Ltd. All rights reserved.