Semi-IPN chitosan/polyvinylpyrrolidone microspheres and films: sustained release and property optimisation

Ozerkan T., Sezer U. A., Gurhan I. D., GÜLÇE İZ S., HASIRCI N.

JOURNAL OF MICROENCAPSULATION, cilt.30, sa.8, ss.762-770, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 8
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/02652048.2013.788084
  • Dergi Adı: JOURNAL OF MICROENCAPSULATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.762-770
  • Anahtar Kelimeler: 5-fluorouracil, chitosan, controlled release, microspheres, polyvinylpyrrolidone, LOADED CHITOSAN MICROSPHERES, POLYVINYL PYRROLIDONE, IN-VITRO, CONTROLLED DELIVERY, HYDROGEL, SYSTEM, ACID, POLYVINYLPYRROLIDONE, DOXORUBICIN, FORMULATION
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

A set of chitosan-polyvinylpyrrolidone (CH-PVP) microspheres were prepared as semi-inter penetrating networks (semi-IPN) and loaded with 5-fluorouracil. In vitro release studies showed faster release for semi-IPN microspheres compared to pure CH samples, and the total release was achieved in about 20-30 days, depending on the composition. In vitro cell studies were achieved against human breast adenocarcinoma cell line cells where adsorption of cells on microspheres with a significant decrease in their number was obtained. Meanwhile, the CH-PVP films, which were prepared with the same compositions as in the microspheres, demonstrated an increase in strength from 66 to 118 MPa as the PVP content was decreased. It can be concluded that the prepared CH-PVP semi-IPN microspheres are novel promising carriers compared to pure CH microspheres since it becomes possible to adjust stability and hydrophilicity of the microspheres as well as the release rates of the drugs from the microspheres by changing the ratio of CH/PVP composition.