Chemoenzymatic synthesis of both enantiomers of 2-chloro-1-(2-furyl)ethanol


Gercek Z., Karakaya D., Demir A.

TETRAHEDRON-ASYMMETRY, cilt.16, ss.1743-1746, 2005 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 16 Konu: 10
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.tetasy.2005.04.007
  • Dergi Adı: TETRAHEDRON-ASYMMETRY
  • Sayfa Sayıları: ss.1743-1746

Özet

Enzyme catalyzed transesterification of rac-2-chloro-1-(2-furyl)ethanol rac-1 using vinyl acetate afforded the enantiomers of 2-chloro-1-(2-furyl)ethanol 1 and 2-chloro-1-(2-furyl)ethyl acetate 2 in high enantiomeric excess. Several lipases were used for the kinetic resolution of racemic 2-chloro-1-(2-furyl)ethanol 1, in which the lipases from Pseudomonas cepacia, Candida antarctica and Candida cylindracea displayed high enantioselectivity towards 1. (C) 2005 Elsevier Ltd. All rights reserved.