Effects of human granulocyte-colony stimulating factor on fracture healing in rats


Bozlar M., Aslan B., Kalaci A., Baktiroglu L., Yanat A., Tasci A.

SAUDI MEDICAL JOURNAL, vol.26, no.8, pp.1250-1254, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 8
  • Publication Date: 2005
  • Title of Journal : SAUDI MEDICAL JOURNAL
  • Page Numbers: pp.1250-1254

Abstract

Objective: Granulocyte colony stimulation factor (G-CSF) is generally used to prevent and cure the neutropenia associated with chemotherapy and bone marrow transplantation. In addition to its effects on neutrophil function, G-CSF was found to have the characteristic of modulating the cytokines in the inflammatory response. Then, the question to answer is whether it has any effect on fracture healing and to what extent? In this study, we test the effects of G-CSF on the healing of tibia fracture in a rat model.