Effects of human granulocyte-colony stimulating factor on fracture healing in rats


Bozlar M., Aslan B., Kalaci A., Baktiroglu L., Yanat A., Tasci A.

SAUDI MEDICAL JOURNAL, cilt.26, sa.8, ss.1250-1254, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Konu: 8
  • Basım Tarihi: 2005
  • Dergi Adı: SAUDI MEDICAL JOURNAL
  • Sayfa Sayıları: ss.1250-1254

Özet

Objective: Granulocyte colony stimulation factor (G-CSF) is generally used to prevent and cure the neutropenia associated with chemotherapy and bone marrow transplantation. In addition to its effects on neutrophil function, G-CSF was found to have the characteristic of modulating the cytokines in the inflammatory response. Then, the question to answer is whether it has any effect on fracture healing and to what extent? In this study, we test the effects of G-CSF on the healing of tibia fracture in a rat model.