A novel one-pot, three-component reaction for the synthesis of isocoumarin-condensed pyrazoles


OZCAN S., DENGİZ Ç., DELIOMEROGLU M. K., ŞAHİN E., BALCI M.

TETRAHEDRON LETTERS, vol.52, no.13, pp.1495-1497, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 13
  • Publication Date: 2011
  • Doi Number: 10.1016/j.tetlet.2011.01.114
  • Journal Name: TETRAHEDRON LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1495-1497
  • Keywords: Pyrazole, Isocoumarin, Homophthalic acids, Homophthalic anhydrides, One-pot three-component reaction, REGIOSELECTIVE SYNTHESIS, BIOLOGICAL EVALUATION, EFFICIENT SYNTHESIS, HOMOPHTHALIC ACID, INHIBITORS, CONSTRUCTION, CHEMISTRY, SKELETON
  • Middle East Technical University Affiliated: Yes

Abstract

The one-pot, three-component reaction of substituted homophthalic anhydrides with hydrazine in DMF as solvent and reactant, at reflux temperature, afforded isochromeno[3,4-c]pyrazole-5(2H)-one derivatives in high yields. The mechanism and roles of the substrates were investigated and it was found that cyclic hydrazides were formed as intermediates. (c) 2011 Elsevier Ltd. All rights reserved.