A novel one-pot, three-component reaction for the synthesis of isocoumarin-condensed pyrazoles

OZCAN S., DENGİZ Ç., DELIOMEROGLU M. K., ŞAHİN E., BALCI M.

TETRAHEDRON LETTERS, cilt.52, sa.13, ss.1495-1497, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 13
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.tetlet.2011.01.114
  • Dergi Adı: TETRAHEDRON LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1495-1497
  • Anahtar Kelimeler: Pyrazole, Isocoumarin, Homophthalic acids, Homophthalic anhydrides, One-pot three-component reaction, REGIOSELECTIVE SYNTHESIS, BIOLOGICAL EVALUATION, EFFICIENT SYNTHESIS, HOMOPHTHALIC ACID, INHIBITORS, CONSTRUCTION, CHEMISTRY, SKELETON
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

The one-pot, three-component reaction of substituted homophthalic anhydrides with hydrazine in DMF as solvent and reactant, at reflux temperature, afforded isochromeno[3,4-c]pyrazole-5(2H)-one derivatives in high yields. The mechanism and roles of the substrates were investigated and it was found that cyclic hydrazides were formed as intermediates. (c) 2011 Elsevier Ltd. All rights reserved.