Asymmetric Synthesis of Trifluoromethyl Substituted Spiro[Indoline‐3,4′‐Pyrano[2,3‐c]Pyrazole] Derivatives with Organocatalysts
CHEMISTRYSELECT, vol.9, pp.1-10, 2024 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 9
- Publication Date: 2024
- Doi Number: 10.1002/slct.202304275
- Journal Name: CHEMISTRYSELECT
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
- Page Numbers: pp.1-10
- Middle East Technical University Affiliated: Yes
Abstract
Spirocyclic compounds have always attracted attention due to
their presence as a structural core in a wide variety of natural
and bioactive molecules and to exhibit pharmaceutical properties. An asymmetric synthesis of spiro[indoline-3,4’-pyrano[2,3-
c]pyrazoles] via Michael addition of trifluoromethyl substituted
pyrazolone to isatylidene ethyl cyanoacetate derivatives was
conducted with excellent enantioselectivities up to 99% and up
to 97% isolated yield at room temperature with using 2 mol%
of bifunctional quinine derived squaramide organocatalysts.