Biomimetic preparation of HA precursors at 37 degrees C in urea- and enzyme urease-containing synthetic body fluids

Bayraktar D., Tas A.

Symposium on Mineralization in Natural and Synthetic Biomaterials, Massachusetts, United States Of America, 29 November - 01 December 1999, vol.599, pp.159-164 identifier

  • Publication Type: Conference Paper / Full Text
  • Volume: 599
  • City: Massachusetts
  • Country: United States Of America
  • Page Numbers: pp.159-164
  • Middle East Technical University Affiliated: No


An important inorganic phase of synthetic bone applications, calcium hydroxyapatite (HA, Ca-10(PO4)(6)(OH)(2)), was prepared as a single-phase and sub-micron bioceramic powder. Carbonated HA precursors were synthesized from calcium nitrate tetrahydrate and diammonium hydrogen phosphate salts dissolved in "synthetic body fluid" (SBF) solutions, containing urea (H2NCONH2) and enzyme urease, under the biomimetic conditions of 37 degrees C and pH 7.4, by using a novel chemical precipitation technique.