BOSENTAN, A NON-SPECIFIC ENDOTHELIN ANTAGONIST, STIMULATES FRACTURE HEALING


Muratli H. H. , Korkusuz F. , KORKUSUZ P., Bicimoglu A., Ercan Z. S.

BIOMEDICAL ENGINEERING-APPLICATIONS BASIS COMMUNICATIONS, vol.19, no.1, pp.37-46, 2007 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.4015/s1016237207000045
  • Title of Journal : BIOMEDICAL ENGINEERING-APPLICATIONS BASIS COMMUNICATIONS
  • Page Numbers: pp.37-46

Abstract

It is assumed that bosentan, a non-selective ET-1 receptor antagonist, will enhance fracture healing. The aim of this prospective randomized controlled study was to investigate the effects of transcutaneous bosentan administration into diaphyseal bone fractures using radiology, histology, prostaglandin E-2 (PGE(2)) and leukotrien C-4 (LTC4) activity measurements.