Atıf İçin Kopyala
Yalcin S., GÜNDÜZ U.
NANOMEDICINE JOURNAL, cilt.8, sa.2, ss.98-105, 2021 (ESCI)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
8
Sayı:
2
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Basım Tarihi:
2021
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Doi Numarası:
10.22038/nmj.2021.08.002
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Dergi Adı:
NANOMEDICINE JOURNAL
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Derginin Tarandığı İndeksler:
Emerging Sources Citation Index (ESCI), Scopus
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Sayfa Sayıları:
ss.98-105
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Anahtar Kelimeler:
Anticancer effect, Breast Cancer, Etoposide, Molecular docking, PHB coated magnetic nanoparticles, siRNA, CANCER-THERAPY, DELIVERY, TUMOR, NANOCARRIERS, RELEASE, OPTIMIZATION, CYTOTOXICITY, FORMULATIONS, ACCURACY, MICELLES
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Orta Doğu Teknik Üniversitesi Adresli:
Evet
Özet
Objective(s): In this work, MRP-1 (Multidrug resistance-associated protein 1) gene expression levels and anticancer activity of siRNA and Etoposide loaded Poly-hydroxybutyrate (PHB) coated magnetic nanoparticles (MNPs) was studied on MCF-7/Sensitive and MCF-7/1000 Etoposide resistance cells. For this purpose, PHB covered iron oxide-based magnetic nanoparticles (PHB-MNPs) were prepared by coprecipitation. We used magnetic nanoparticles because they include highly targeted to tumors in vivo cancer therapy.