NANOMEDICINE JOURNAL, vol.8, no.2, pp.98-105, 2021 (ESCI)
Article / Article
Emerging Sources Citation Index (ESCI), Scopus
Anticancer effect, Breast Cancer, Etoposide, Molecular docking, PHB coated magnetic nanoparticles, siRNA, CANCER-THERAPY, DELIVERY, TUMOR, NANOCARRIERS, RELEASE, OPTIMIZATION, CYTOTOXICITY, FORMULATIONS, ACCURACY, MICELLES
Middle East Technical University Affiliated:
Objective(s): In this work, MRP-1 (Multidrug resistance-associated protein 1) gene expression levels and anticancer activity of siRNA and Etoposide loaded Poly-hydroxybutyrate (PHB) coated magnetic nanoparticles (MNPs) was studied on MCF-7/Sensitive and MCF-7/1000 Etoposide resistance cells. For this purpose, PHB covered iron oxide-based magnetic nanoparticles (PHB-MNPs) were prepared by coprecipitation. We used magnetic nanoparticles because they include highly targeted to tumors in vivo cancer therapy.