Synthesis and biological activity of siRNA and Etoposide with magnetic nanoparticles on drug resistance model MCF-7 Cells: Molecular docking study with MRP1 enzyme

Yalcin S., GÜNDÜZ U.

NANOMEDICINE JOURNAL, vol.8, no.2, pp.98-105, 2021 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.22038/nmj.2021.08.002
  • Journal Name: NANOMEDICINE JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.98-105
  • Keywords: Anticancer effect, Breast Cancer, Etoposide, Molecular docking, PHB coated magnetic nanoparticles, siRNA, CANCER-THERAPY, DELIVERY, TUMOR, NANOCARRIERS, RELEASE, OPTIMIZATION, CYTOTOXICITY, FORMULATIONS, ACCURACY, MICELLES
  • Middle East Technical University Affiliated: Yes

Abstract

Objective(s): In this work, MRP-1 (Multidrug resistance-associated protein 1) gene expression levels and anticancer activity of siRNA and Etoposide loaded Poly-hydroxybutyrate (PHB) coated magnetic nanoparticles (MNPs) was studied on MCF-7/Sensitive and MCF-7/1000 Etoposide resistance cells. For this purpose, PHB covered iron oxide-based magnetic nanoparticles (PHB-MNPs) were prepared by coprecipitation. We used magnetic nanoparticles because they include highly targeted to tumors in vivo cancer therapy.