Genetic polymorphisms of vitamin D3 metabolizing CYP24A1 and CYP2R1 enzymes in Turkish patients with ischemic stroke

ÖZÇELİK A., ÖNER T., Demirdogen B. C., BEK V. S., DEMİRKAYA Ş., ADALI O.

NEUROLOGICAL RESEARCH, cilt.40, sa.5, ss.364-371, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 5
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/01616412.2018.1446281
  • Dergi Adı: NEUROLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.364-371
  • Anahtar Kelimeler: CYP24A1, CYP2R1, single nucleotide polymorphism, vitamin D, ischemic stroke, 25-HYDROXYVITAMIN D, CARDIOVASCULAR-DISEASE, DENDRITIC CELLS, D DEFICIENCY, 1,25-DIHYDROXYVITAMIN D-3, ENDOTHELIAL DYSFUNCTION, CYP27B1 POLYMORPHISMS, ASSOCIATION, SUSCEPTIBILITY, RATS
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Objective: Vitamin D deficiency is known as an important risk factor in pathogenesis of atherosclerosis, which contributes to stroke development. Genetic variations including single nucleotide polymorphisms (SNPs) in enzymes involved in vitamin D metabolism can affect susceptibility to the development of stroke. Therefore, the objective of this study was to investigate the association between polymorphisms of vitamin D metabolizing enzymes (rs927650 SNP in CYP24A1, and rs10741657 SNP in CYP2R1 genes,) and ischemic stroke risk in Turkish population.