Genetic polymorphisms of vitamin D3 metabolizing CYP24A1 and CYP2R1 enzymes in Turkish patients with ischemic stroke


ÖZÇELİK A., ÖNER T., Demirdogen B. C. , BEK V. S. , DEMİRKAYA Ş., ADALI O.

NEUROLOGICAL RESEARCH, vol.40, no.5, pp.364-371, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 5
  • Publication Date: 2018
  • Doi Number: 10.1080/01616412.2018.1446281
  • Title of Journal : NEUROLOGICAL RESEARCH
  • Page Numbers: pp.364-371

Abstract

Objective: Vitamin D deficiency is known as an important risk factor in pathogenesis of atherosclerosis, which contributes to stroke development. Genetic variations including single nucleotide polymorphisms (SNPs) in enzymes involved in vitamin D metabolism can affect susceptibility to the development of stroke. Therefore, the objective of this study was to investigate the association between polymorphisms of vitamin D metabolizing enzymes (rs927650 SNP in CYP24A1, and rs10741657 SNP in CYP2R1 genes,) and ischemic stroke risk in Turkish population.