Genetic polymorphisms of vitamin D3 metabolizing CYP24A1 and CYP2R1 enzymes in Turkish patients with ischemic stroke

ÖZÇELİK A., ÖNER T., Demirdogen B. C., BEK V. S., DEMİRKAYA Ş., ADALI O.

NEUROLOGICAL RESEARCH, vol.40, no.5, pp.364-371, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 5
  • Publication Date: 2018
  • Doi Number: 10.1080/01616412.2018.1446281
  • Journal Name: NEUROLOGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.364-371
  • Keywords: CYP24A1, CYP2R1, single nucleotide polymorphism, vitamin D, ischemic stroke, 25-HYDROXYVITAMIN D, CARDIOVASCULAR-DISEASE, DENDRITIC CELLS, D DEFICIENCY, 1,25-DIHYDROXYVITAMIN D-3, ENDOTHELIAL DYSFUNCTION, CYP27B1 POLYMORPHISMS, ASSOCIATION, SUSCEPTIBILITY, RATS
  • Middle East Technical University Affiliated: Yes

Abstract

Objective: Vitamin D deficiency is known as an important risk factor in pathogenesis of atherosclerosis, which contributes to stroke development. Genetic variations including single nucleotide polymorphisms (SNPs) in enzymes involved in vitamin D metabolism can affect susceptibility to the development of stroke. Therefore, the objective of this study was to investigate the association between polymorphisms of vitamin D metabolizing enzymes (rs927650 SNP in CYP24A1, and rs10741657 SNP in CYP2R1 genes,) and ischemic stroke risk in Turkish population.