Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population

Bilgin E., Can Demirdöğen B., Ozcelik A. T., Demirkaya S., Adalı O.

NEUROLOGICAL RESEARCH, vol.41, pp.118-124, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41
  • Publication Date: 2019
  • Doi Number: 10.1080/01616412.2018.1544385
  • Journal Name: NEUROLOGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.118-124
  • Keywords: Genetic polymorphism, Glutathione S transferase omega 1, Glutathione S transferase omega 2, ischemia, stroke, SNPs, 1 A140D, SMOKING, ATHEROSCLEROSIS, GENOTYPES, GSTM1, GSTT1
  • Middle East Technical University Affiliated: Yes

Abstract

Objectives: Oxidative stress is a known risk factor for the pathogenesis of atherosclerosis, the main cause of ischemic stroke. Glutathione S-transferase (GST) omega-1 and omega-2, members of phase II enzymes, play a role in the antioxidant system. The single nucleotide polymorphisms (SNPs), C419A and A424G in GST omega genes can cause a decrease in enzyme activity. The aim of this study was to investigate the possible association between these polymorphisms and ischemic stroke risk in a Turkish population.