NEUROLOGICAL RESEARCH, vol.41, pp.118-124, 2019 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Genetic polymorphism, Glutathione S transferase omega 1, Glutathione S transferase omega 2, ischemia, stroke, SNPs, 1 A140D, SMOKING, ATHEROSCLEROSIS, GENOTYPES, GSTM1, GSTT1
Middle East Technical University Affiliated:
Objectives: Oxidative stress is a known risk factor for the pathogenesis of atherosclerosis, the main cause of ischemic stroke. Glutathione S-transferase (GST) omega-1 and omega-2, members of phase II enzymes, play a role in the antioxidant system. The single nucleotide polymorphisms (SNPs), C419A and A424G in GST omega genes can cause a decrease in enzyme activity. The aim of this study was to investigate the possible association between these polymorphisms and ischemic stroke risk in a Turkish population.