Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population

Bilgin E., Can Demirdöğen B., Ozcelik A. T., Demirkaya S., Adalı O.

NEUROLOGICAL RESEARCH, cilt.41, ss.118-124, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/01616412.2018.1544385
  • Dergi Adı: NEUROLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.118-124
  • Anahtar Kelimeler: Genetic polymorphism, Glutathione S transferase omega 1, Glutathione S transferase omega 2, ischemia, stroke, SNPs, 1 A140D, SMOKING, ATHEROSCLEROSIS, GENOTYPES, GSTM1, GSTT1
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Objectives: Oxidative stress is a known risk factor for the pathogenesis of atherosclerosis, the main cause of ischemic stroke. Glutathione S-transferase (GST) omega-1 and omega-2, members of phase II enzymes, play a role in the antioxidant system. The single nucleotide polymorphisms (SNPs), C419A and A424G in GST omega genes can cause a decrease in enzyme activity. The aim of this study was to investigate the possible association between these polymorphisms and ischemic stroke risk in a Turkish population.