Protein-based materials in load-bearing tissue-engineering applications

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Sayin E., Baran E. T., Hasirci V.

REGENERATIVE MEDICINE, cilt.9, sa.5, ss.687-701, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 9 Sayı: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.2217/rme.14.52
  • Dergi Adı: REGENERATIVE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.687-701
  • Anahtar Kelimeler: biomaterial, load bearing, protein, regeneration, scaffold, tissue engineering, SILK FIBROIN SCAFFOLDS, MECHANICAL-PROPERTIES, COLLAGEN SCAFFOLDS, STEM-CELLS, COMPOSITE SCAFFOLDS, ARTICULAR-CARTILAGE, ELASTIN, BONE, REGENERATION, GELATIN
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Proteins such as collagen and elastin are robust molecules that constitute nanocomponents in the hierarchically organized ultrastructures of bone and tendon as well as in some of the soft tissues that have load-bearing functions. In the present paper, the macromolecular structure and function of the proteins are reviewed and the potential of mammalian and non-mammalian proteins in the engineering of load-bearing tissue substitutes are discussed. Chimeric proteins have become an important structural biomaterial source and their potential in tissue engineering is highlighted. Processing of proteins challenge investigators and in this review rapid prototyping and microfabrication are proposed as methods for obtaining precisely defined custom-built tissue engineered structures with intrinsic microarchitecture.