Tissue engineering of oral mucosa: a shared concept with skin

Kinikoglu B., Damour O., Hasirci V.

JOURNAL OF ARTIFICIAL ORGANS, cilt.18, sa.1, ss.8-19, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s10047-014-0798-5
  • Dergi Adı: JOURNAL OF ARTIFICIAL ORGANS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.8-19
  • Anahtar Kelimeler: Tissue engineering, Biomaterials, Polymeric scaffold, Oral mucosa, Skin, NORMAL HUMAN KERATINOCYTES, ELASTIN-LIKE POLYPEPTIDE, EPITHELIAL-CELL SHEETS, FREE CULTURE-SYSTEM, GROWTH-FACTOR, COLLAGEN NANOFIBERS, ARTIFICIAL SKIN, DERMAL MATRIX, STEM-CELLS, EQUIVALENT
  • Orta Doğu Teknik Üniversitesi Adresli: Hayır

Özet

Tissue-engineered oral mucosa, in the form of epithelial cell sheets or full-thickness oral mucosa equivalents, is a potential solution for many patients with congenital defects or with tissue loss due to diseases or tumor excision following a craniofacial cancer diagnosis. In the laboratory, it further serves as an in vitro model, alternative to in vivo testing of oral care products, and provides insight into the behavior of the oral mucosal cells in healthy and pathological tissues. This review covers the old and new generation scaffold types and materials used in oral mucosa engineering; discusses similarities and differences between oral mucosa and skin, the methods developed to reconstruct oral mucosal defects; and ends with future perspectives on oral mucosa engineering.