Evolutionary paths to mammalian longevity through the lens of gene expression
EMBO JOURNAL, cilt.42, sa.17, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Editöre Mektup
- Cilt numarası: 42 Sayı: 17
- Basım Tarihi: 2023
- Doi Numarası: 10.15252/embj.2023114879
- Dergi Adı: EMBO JOURNAL
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Veterinary Science Database, DIALNET, Nature Index
- Orta Doğu Teknik Üniversitesi Adresli: Hayır
Özet
The natural variation in mammalian longevity and its underlying mechanisms remain an active area of aging research. In the latest issue of The EMBO Journal, Liu et al (2023) analyze gene expression levels in 103 mammalian species across three tissues, revealing tissue-specific associations between gene expression patterns and longevity. Remarkably, the study suggests that methionine restriction, a strategy shown to increase lifespan, may extend beyond artificial interventions and is similarly employed by natural selection.