Synthesis of 2-aziridinyl phosphonates by modified Gabriel-Cromwell reaction and their antibacterial activities

Doğan, ÖZDEMİR; Babiz, Hakan; Gözen, AYŞE; Budak, Songul

doi:10.1016/j.ejmech.2011.03.037

Synthesis of 2-aziridinyl phosphonates by modified Gabriel-Cromwell reaction and their antibacterial activities

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Doğan Ö., Babiz H., Gözen A. G., Budak S.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.46, pp.2485-2489, 2011 (SCI-Expanded)

Publication Type: Article / Article
Volume: 46
Publication Date: 2011
Doi Number: 10.1016/j.ejmech.2011.03.037
Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.2485-2489
Middle East Technical University Affiliated: Yes

Abstract

A set of new aziridinyl phosphonates (4a-g) were synthesized by using the Gabriel-Cromwell reaction and its modified version developed in this study and their structures confirmed by HRMS, IR. and NMR spectra. All the compounds were screened for their antibacterial activity. They all showed comparable moderate to good growth inhibitory activity in reference to ampicillin and streptomycin. (C) 2011 Elsevier Masson SAS. All rights reserved.