Towards the asymmetric synthesis of ascochlorin


DOĞAN Ö. , Oppolzer W.

TURKISH JOURNAL OF CHEMISTRY, cilt.25, ss.273-281, 2001 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 25 Konu: 3
  • Basım Tarihi: 2001
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Sayfa Sayıları: ss.273-281

Özet

A synthetic approach is described to the asymmetric synthesis of ascochlorin (1), an antiviral antibiotic, based on the construction of a sesquiterpene unit via asymmetric Diels-Alder reaction of tigloyl sultam 4 & butadiene, and the introduction of the aromatic side chain (C9-C12 unit) by employing cuprate chemistry.