Integration of topological measures for eliminating non-specific interactions in protein interaction networks

BAYIR M. A., GUNEY T. D., Can T.

DISCRETE APPLIED MATHEMATICS, cilt.157, sa.10, ss.2416-2424, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 157 Sayı: 10
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.dam.2008.06.034
  • Dergi Adı: DISCRETE APPLIED MATHEMATICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2416-2424
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

High-throughput protein interaction assays aim to provide a comprehensive list of interactions that govern the biological processes in a cell. These large-scale sets of interactions, represented as protein-protein interaction networks, are often analyzed by computational methods for detailed biological interpretation. However, as a result of the tradeoff between speed and accuracy, the interactions reported by high-throughput techniques occasionally include non-specific (i.e., false-positive) interactions. Unfortunately, many computational methods are sensitive to noise in protein interaction networks; and therefore they are not able to make biologically accurate inferences.