The potential of ETS-10 as a Lewis acid catalyst was investigated using the MPV reaction at one atmosphere total pressure and 273 K. ETS-10 was hypothesized to be a potential Lewis acid catalyst as it has titanium in octahedral symmetry, which is the symmetry shown in zeolite Beta to be the most active site for the Lewis acid catalyzed Meerwein-Ponndorf-Verley (MPV) reaction. The MPV reaction is a hydrogen transfer reaction that can be used for obtaining information about the structure and performance of catalysts by comparing the product selectivities and catalytic activities. Due to their similar structures, the catalytic activity of ETS-10 was compared to zeolite Beta samples that were space-grown (flight, fewer defects) and to their earth-grown terrestrial controls. The higher tr-alcohol selectivity (i.e., trans-4-tert-butylcyclohexanol, similar to 80% vs. 40%) observed over ETS-10 was attributed to a larger volume being available in the pores of ETS-10 compared to the zeolite Beta samples. By-product formation (i.e., 4-tert-butylcyclohexene) was significantly less over ETS-10 (similar to 5%) in comparison with the zeolite Beta samples (flight and control; similar to 35%). These results reaffirm the octahedral symmetry as the Lewis active site for the MPV reaction, and illustrate that ETS-10 is a good catalyst for MPV type reactions.