Optical Properties of Active Pharmaceutical Ingredients in Terahertz Region

AYTEKİN Y. S., Kokturk M., Adam Z., Korter T., Heilweil E., ESENTÜRK O.

2019 44th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz), Paris, France, 1 - 06 September 2019, (Full Text) identifier

  • Publication Type: Conference Paper / Full Text
  • Doi Number: 10.1109/irmmw-thz.2019.8874394
  • City: Paris, France
  • Middle East Technical University Affiliated: Yes

Abstract

In this study Terahertz (THz) spectra of several commonly used active pharmaceutical ingredients are reported. Results showed that all the API’s had unique bands associated with the structures allowing to analyse both qualitatively and quantitatively. The liq. nitrogen temperature and solid state and gas phase theoretical analysis of meloxicam have also been carried out. In addition, the transparency of the drug packaging materials like plastic blisters, cartons were checked to see the technique’s ability for in situ nondestructive penetrating analysis.