PFAM catalyzed enantioselective diethylzinc addition to imines

DOĞAN Ö., ÇAĞLI E.

TURKISH JOURNAL OF CHEMISTRY, vol.39, no.2, pp.290-296, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.3906/kim-1410-29
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.290-296
  • Keywords: Chiral amines, diethylzinc addition, sulfonyl imines, phosphinoyl imines, FERROCENYL AMIDOPHOSPHINE LIGAND, ORGANOMETALLIC REAGENTS, DIALKYLZINC REAGENTS, ASYMMETRIC ADDITION, BONDS
  • Middle East Technical University Affiliated: Yes

Abstract

Chiral amines are important starting materials for the synthesis of biologically important compounds. Enantioselective addition of dialkylzinc reagents to imines is a reliable method for the synthesis of these compounds. Different chiral catalysts were developed and used for this method. Phosphorous based PFAM catalysts were tried for the first time in the enantioselective synthesis of amines by reacting diethylzinc with N-sulfonyl imines and N-diphenylphosphinoyl imines. Chiral amines were isolated with moderate to acceptable yields and enantioselectivities.