PFAM catalyzed enantioselective diethylzinc addition to imines

DOĞAN Ö., ÇAĞLI E.

TURKISH JOURNAL OF CHEMISTRY, cilt.39, sa.2, ss.290-296, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3906/kim-1410-29
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.290-296
  • Anahtar Kelimeler: Chiral amines, diethylzinc addition, sulfonyl imines, phosphinoyl imines, FERROCENYL AMIDOPHOSPHINE LIGAND, ORGANOMETALLIC REAGENTS, DIALKYLZINC REAGENTS, ASYMMETRIC ADDITION, BONDS
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Chiral amines are important starting materials for the synthesis of biologically important compounds. Enantioselective addition of dialkylzinc reagents to imines is a reliable method for the synthesis of these compounds. Different chiral catalysts were developed and used for this method. Phosphorous based PFAM catalysts were tried for the first time in the enantioselective synthesis of amines by reacting diethylzinc with N-sulfonyl imines and N-diphenylphosphinoyl imines. Chiral amines were isolated with moderate to acceptable yields and enantioselectivities.