Mechanisms of Dietary Response in Mice and Primates: A Role for EGR1 in Regulating the Reaction to Human-Specific Nutritional Content

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Weng K., Hu H., Xu A. G., Khaitovich P., Somel M.

PLOS ONE, cilt.7, sa.8, 2012 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 7 Sayı: 8
• Basım Tarihi: 2012
• Doi Numarası: 10.1371/journal.pone.0043915
• Dergi Adı: PLOS ONE
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Orta Doğu Teknik Üniversitesi Adresli: Hayır

Özet

Background: Humans have a widely different diet from other primate species, and are dependent on its high nutritional content. The molecular mechanisms responsible for adaptation to the human diet are currently unknown. Here, we addressed this question by investigating whether the gene expression response observed in mice fed human and chimpanzee diets involves the same regulatory mechanisms as expression differences between humans and chimpanzees.