Boron doped hydroxyapatites in biomedical applications

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Uysal İ., Yılmaz B., Evis Z.

Bor Dergisi, vol.5, no.4, pp.199-208, 2020 (Peer-Reviewed Journal)

  • Publication Type: Article / Review
  • Volume: 5 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.30728/boron.734804
  • Journal Name: Bor Dergisi
  • Journal Indexes: TR DİZİN (ULAKBİM)
  • Page Numbers: pp.199-208


Hydroxyapatite has been widely used in biomedical applications as a coating
material for implant surfaces, a drug carrier, a scaffold or composite for bone
tissue engineering applications. The highly ionic structure of hydroxyapatite allows
doping of various ions, resulting in an improvement in its properties. Boron is one
of the elements which can be doped into hydroxyapatite structure by replacing
phosphate (PO
43-) or hydroxyl (OH-) sites to obtain scaffolds for bone tissue
engineering applications or a coating material for metal substrates. Although the
effects of supplemental boron on bone, liver, and brain metabolism have been
shown to have important results as a nutrient, there are very few studies in the
literature on the use of boron-doped hydroxyapatite in the biomedical field. In this
review, the details of synthesis methods and functional groups of boron-doped
hydroxyapatite were tabulated. Generally, the addition of boron leads to the
formation of rod-like morphology, while the density and Vicker’s microhardness
of hydroxyapatite decrease. Thermal stability and electrical insulation properties
were observed to improve with boron doping. Boron was also shown to increase
biodegradability, bioactivity as well as cell proliferation and differentiation of
different cell types on the surface of hydroxyapatite.