Missense Genetic Polymorphisms of Microsomal (<i>EPHX1</i>) and Soluble Epoxide Hydrolase (<i>EPHX2</i>) and Their Relation to the Risk of Large Artery Atherosclerotic Ischemic Stroke in a Turkish Population.

Demirdogen B. C., Micoogullari Y., Ozcelik A. T., Adalı O.

Neuropsychiatric disease and treatment, vol.16, pp.3251-3265, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16
  • Publication Date: 2021
  • Doi Number: 10.2147/ndt.s233992
  • Journal Name: Neuropsychiatric disease and treatment
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Psycinfo, Directory of Open Access Journals
  • Page Numbers: pp.3251-3265
  • Keywords: Arg287Gln, epoxyeicosatrienoic acids, EETs, His139Arg, SNP, Tyr113His, GLUTATHIONE-S-TRANSFERASE, DIHYDROXYEICOSATRIENOIC ACIDS, EPOXYEICOSATRIENOIC ACIDS, CYTOCHROME P4501A1, THERAPEUTIC TARGET, INSULIN-RESISTANCE, SEQUENCE VARIATION, GLOBAL BURDEN, ASSOCIATION, SUSCEPTIBILITY
  • Middle East Technical University Affiliated: Yes

Abstract

Purpose: Soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH) both catalyze the metabolism of epoxyeicosatrienoic acids (EETs), lipid signaling molecules that are protective against ischemic brain injury owing to their participation in the regulation of vascular tone and cerebral blood flow. In addition, mEH metabolizes polycyclic aromatic hydrocarbons, one of the causative factors of atherosclerotic lesion development. In this study, we aimed to investigate the association of enzyme activity-modifying missense single nucleotide polymorphisms (SNPs) of the sEH gene (EPHX2) and mEH gene (EPHX1) and ischemic stroke risk in a Turkish population.