The pressure dependence of the vibrational frequencies of six Raman modes is analyzed in phase II of solid benzene. The frequency shifts 1/nu(partial derivative nu/partial derivative P)(T) of those Raman modes are deduced from this analysis and they are related to the isothermal compressibility kappa(T)= -(1/V)(partial derivative V/partial derivative P)(T) through a constant isothermal mode Gruneisen parameter gamma(T) in phase II of solid benzene. The kappa(T) values predicted here are compared with the kappa(T) obtained from the volumetric measurements in this phase. It is shown here that the isothermal compressibility can be predicted from the vibrational frequencies measured in phase II of solid benzene. (C) 2011 Elsevier B.V. All rights reserved.