Surface Characterization and Biocompatibility of Selenium-Doped Hydroxyapatite Coating on Titanium Alloy

Yilmaz B., EVİS Z., TEZCANER A., BANERJEE S.

INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, vol.13, no.6, pp.1059-1068, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.1111/ijac.12577
  • Journal Name: INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1059-1068
  • Keywords: hydroxyapatite, selenium, selenium compounds, coatings, dopants, doping, CALCIUM-PHOSPHATE, CANCER RISK, BODY-FLUID, SUPPLEMENTATION, CYTOTOXICITY, TEMPERATURE, EXPRESSION, CARCINOMA, APOPTOSIS, SELENATE
  • Middle East Technical University Affiliated: Yes

Abstract

Selenium-doped hydroxyapatite (HA) was biomimetically coated on Ti6Al4V plates with the aim of combining the anticancer and antibacterial properties of selenium with the biocompatibility and bioactivity of HA. For the coating process, the composition of 1.5 x SBF (solution with ion concentrations at 1.5 times that of simulated body fluid, SBF) was modified to include 0.15 mM selenate (SeO42-) ion. The selenium-doped HA coating was characterized by several methods, such as scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy. The cytotoxicity of selenium on osteoblast and osteosarcoma cells was determined. The coating was shown to inhibit the growth of Staphylococcus epidermidis.