Gene expression analysis of drug-resistant MCF-7 cells: implications for relation to extracellular matrix proteins

Iseri O. D., Kars M. D., Arpaci F., GÜNDÜZ U.

CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol.65, no.3, pp.447-455, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.1007/s00280-009-1048-z
  • Journal Name: CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.447-455
  • Keywords: Multidrug resistance, cDNA microarray, ECM, Integrin, MMP, ADAM, HUMAN COLON-CARCINOMA, BREAST-CANCER CELLS, MULTIDRUG-RESISTANCE, P-GLYCOPROTEIN, ENDOTHELIAL-CELLS, INDUCED APOPTOSIS, TISSUE INHIBITOR, GROWTH-FACTOR, TUMOR-CELLS, FIBRONECTIN
  • Middle East Technical University Affiliated: Yes

Abstract

Since multidrug resistance is a multifactorial phenomenon, a large-scale expression analysis of drug-resistant cells by using high-density oligonucleotide microarrays may provide information about new candidate genes contributing to resistance. Extracellular matrix (ECM) is responsible for many aspects of proliferation and invasive/metastatic behavior of tumor cells. This study demonstrates alterations in gene expression levels of several ECM components, matrix metalloproteinases (MMPs), adamalysins (ADAMs and ADAMTSs) and tissue inhibitors of metalloproteinases (TIMPs) in paclitaxel, docetaxel, vincristine and doxorubicin-resistant MCF-7 cells.