Investigation and scale-up of hot-melt coating of pharmaceuticals in fluidized beds

KÜLAH G., Kaya O.

POWDER TECHNOLOGY, cilt.208, sa.1, ss.175-184, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 208 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.powtec.2010.12.016
  • Dergi Adı: POWDER TECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.175-184
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

This study was performed to investigate and scale-up the hot-melt coating process in fluidized beds. A series of well-designed experiments was carried out in a pilot scale unit with 20 kg product capacity to investigate the effects of process variables on the efficiency of the coating of Cefuroxime Axetil with stearic acid. Results showed that the efficiency is at the highest when the fluidization air flow rate is adjusted by considering the changes in the amount of materials present in the unit as well as the changes in the terminal velocities of particles during the process.