© 2022 Elsevier Ltd and Techna Group S.r.l.Ti6Al4V alloy is successfully used as implant material in dental and orthopedic surgeries for years due to its much better compatibility, lower density, corrosion resistance, etc. compared to the other metals. Meantime, modification of the surface of these alloys is needed to enhance material-tissue interaction and osteointegration between the implant and the bone. In this study, Ti6Al4V alloy surfaces were modified by application of RF magnetron sputtering technique and coated with zinc (Zn) doped hydroxyapatite (HAp). The obtained coating was very stable with highly crystalline structure, demonstrated enhanced corrosion resistance, osteointegration and antimicrobial effectiveness against Escherichia coli (E. coli) bacteria.