ARID3B expression in primary breast cancers and breast cancer-derived cell lines

ERDOGAN A. S. O., OZDEMIRLER N., ÖYKEN M., ALPER M., Erson-Bensan A. E.

CELLULAR ONCOLOGY, vol.37, no.4, pp.289-296, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.1007/s13402-014-0185-5
  • Journal Name: CELLULAR ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.289-296
  • Keywords: ARID3B expression, Breast cancer, Estrogen receptor, ERBB2, DNA-BINDING PROTEINS, FAMILY, MIR-125A, GROWTH, MIRNAS
  • Middle East Technical University Affiliated: Yes

Abstract

ARID3B (AT-rich interaction domain 3) is a member of the family of ARID proteins, which constitutes evolutionarily conserved transcription factors implicated in normal development, differentiation, cell cycle regulation and chromatin remodeling. In addition, ARID3B has been linked to cellular immortalization, epithelial-mesenchymal transition (EMT) and tumorigenesis. Given the emerging role of ARID3B in tumor development, we examined its expression in primary patient-derived breast cancer samples and breast cancer-derived cell lines.