Fullerene-Based Mimics of Biocatalysts Show Remarkable Activity and Modularity.

Gülseren G., Saylam A., Marion A., Özçubukçu S.

ACS applied materials & interfaces, cilt.13, sa.38, ss.45854-45863, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 38
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1021/acsami.1c11516
  • Dergi Adı: ACS applied materials & interfaces
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Compendex, EMBASE, INSPEC, MEDLINE
  • Sayfa Sayıları: ss.45854-45863
  • Anahtar Kelimeler: fullerene, fullerenol, biocatalysis, enzyme mimic, amino acids, molecular dynamics, QM/MM, PEPTIDE NANOFIBERS, ARTIFICIAL ENZYMES, CATALYSIS, PROTEASES, ARCHITECTURE, ANTIBODIES, PROTEIN, SITES, TRIAD, ACID
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

© 2021 American Chemical Society.The design of catalysts with greater control over catalytic activity and stability is a major challenge with substantial impact on fundamental chemistry and industrial applications. Due to their unparalleled diversity, selectivity, and efficiency, enzymes are promising models for next-generation catalysts, and considerable efforts have been devoted to incorporating the principles of their mechanisms of action into artificial systems. We report a heretofore undocumented catalyst design that introduces fullerenes to the field of biocatalysis, which we refer to as fullerene nanocatalysts, and that emulates enzymatic active sites through multifunctional self-assembled nanostructures. As a proof-of-concept, we mimicked the reactivity of hydrolases using fullerene nanocatalysts functionalized with the basic components of the parent enzyme with remarkable activity. Owing to the versatile amino acid-based functionalization repertoire of fullerene nanocatalysts, these next-generation carbon/biomolecule hybrids have potential to mimic the activity of other families of enzymes and, therefore, offer new perspectives for the design of biocompatible, high-efficiency artificial nanocatalysts.