C-4 ' Truncated carbocyclic formycin derivatives

Zhou J., Yang M., Akdag A., Schneller S. W.

TETRAHEDRON, vol.62, no.29, pp.7009-7013, 2006 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 62 Issue: 29
  • Publication Date: 2006
  • Doi Number: 10.1016/j.tet.2006.04.068
  • Journal Name: TETRAHEDRON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.7009-7013
  • Keywords: formycin, carbocyclic C-nucleosides, epoxide ring opening, antiviral testing, C-NUCLEOSIDE, ANTIVIRAL ACTIVITY, CINE-SUBSTITUTION, ANALOGS, ARISTEROMYCIN, 1,4-DINITROPYRAZOLES, INHIBITORS
  • Middle East Technical University Affiliated: Yes

Abstract

Formycin is a naturally occurring C-glycoside (C-nucleoside) that possesses antitumor, antibacterial, antifungal, and antiviral activity. In connection with our ongoing interest in the design and syntheses of C-nucleoside derived antiviral agents this report describes the preparation of carbocyclic formycin and its 7-hydroxy (oxo) analog lacking the C-4' hydroxylmethylene moiety in racemic form (4 and 6, respectively). An antiviral analysis of (+/-)-4 did not disclose any activity. (c) 2006 Elsevier Ltd. All rights reserved.