C-4 ' Truncated carbocyclic formycin derivatives

Zhou J., Yang M., Akdag A., Schneller S. W.

TETRAHEDRON, cilt.62, sa.29, ss.7009-7013, 2006 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 29
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.tet.2006.04.068
  • Dergi Adı: TETRAHEDRON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.7009-7013
  • Anahtar Kelimeler: formycin, carbocyclic C-nucleosides, epoxide ring opening, antiviral testing, C-NUCLEOSIDE, ANTIVIRAL ACTIVITY, CINE-SUBSTITUTION, ANALOGS, ARISTEROMYCIN, 1,4-DINITROPYRAZOLES, INHIBITORS
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Formycin is a naturally occurring C-glycoside (C-nucleoside) that possesses antitumor, antibacterial, antifungal, and antiviral activity. In connection with our ongoing interest in the design and syntheses of C-nucleoside derived antiviral agents this report describes the preparation of carbocyclic formycin and its 7-hydroxy (oxo) analog lacking the C-4' hydroxylmethylene moiety in racemic form (4 and 6, respectively). An antiviral analysis of (+/-)-4 did not disclose any activity. (c) 2006 Elsevier Ltd. All rights reserved.