C-4 ' Truncated carbocyclic formycin derivatives


Zhou J., Yang M., Akdag A. , Schneller S. W.

TETRAHEDRON, cilt.62, ss.7009-7013, 2006 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 62 Konu: 29
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.tet.2006.04.068
  • Dergi Adı: TETRAHEDRON
  • Sayfa Sayıları: ss.7009-7013

Özet

Formycin is a naturally occurring C-glycoside (C-nucleoside) that possesses antitumor, antibacterial, antifungal, and antiviral activity. In connection with our ongoing interest in the design and syntheses of C-nucleoside derived antiviral agents this report describes the preparation of carbocyclic formycin and its 7-hydroxy (oxo) analog lacking the C-4' hydroxylmethylene moiety in racemic form (4 and 6, respectively). An antiviral analysis of (+/-)-4 did not disclose any activity. (c) 2006 Elsevier Ltd. All rights reserved.