Recent advances in the synthesis of fused heterocycles with new skeletons via alkyne cyclization

BALCI M.

TETRAHEDRON LETTERS, vol.61, no.24, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 61 Issue: 24
  • Publication Date: 2020
  • Doi Number: 10.1016/j.tetlet.2020.151994
  • Journal Name: TETRAHEDRON LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chimica, EMBASE, Veterinary Science Database
  • Keywords: Fused-heterocycles, Alkyne, Allene, AuCl3 as catalyst, DFT calculations, PYRROLO-PYRAZINES, N-HETEROCYCLES, DERIVATIVES, CHROMENOPYRIDINES, CHEMISTRY, CATALYST, DESIGN, SERIES, ROUTE
  • Middle East Technical University Affiliated: No

Abstract

An account of our most recent developments on the synthesis of various fused heterocycles via alkyne cyclization is presented. The synthetic strategy involves N- or O-propargylation of heteroaromatic or aromatic compounds followed by intramolecular gold-catalyzed or NaH-promoted intramolecular cyclization reactions. This synthetic strategy represents a reasonable methodology for the construction of hitherto unknown skeletons. (C) 2020 Elsevier Ltd. All rights reserved.