Drug resistant breast cancer cells overexpress ETS1 gene

Kars M. D., Iseri O. D., GÜNDÜZ U.

BIOMEDICINE & PHARMACOTHERAPY, vol.64, no.7, pp.458-462, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 7
  • Publication Date: 2010
  • Doi Number: 10.1016/j.biopha.2010.01.008
  • Journal Name: BIOMEDICINE & PHARMACOTHERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.458-462
  • Keywords: ETS1, MCF-7, MDR1, Matrix metalloproteinases, Microarray analysis, CHRONIC LYMPHOCYTIC-LEUKEMIA, TRANSCRIPTION FACTOR, MULTIDRUG-RESISTANCE, ANTICANCER AGENTS, P53 GENE, EXPRESSION, MUTATIONS, TP53, LINES, ANGIOGENESIS
  • Middle East Technical University Affiliated: Yes

Abstract

Purpose. - Multidrug resistance (MDR) is resistance to wide range of structurally unrelated anticancer agents. MDR is a serious limitation to the effective chemotherapy. Involvement of ETS1 overexpression in upregulation of MDR1 gene expression is implicated. In the present study the aim was to assess the involvement of ETS1 and the genes, which encode the proteins interacting with ETS1 in drug resistant MCF-7 breast cancer cells.