Drug resistant breast cancer cells overexpress ETS1 gene


Kars M. D. , Iseri O. D. , GÜNDÜZ U.

BIOMEDICINE & PHARMACOTHERAPY, cilt.64, ss.458-462, 2010 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 64 Konu: 7
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.biopha.2010.01.008
  • Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
  • Sayfa Sayısı: ss.458-462

Özet

Purpose. - Multidrug resistance (MDR) is resistance to wide range of structurally unrelated anticancer agents. MDR is a serious limitation to the effective chemotherapy. Involvement of ETS1 overexpression in upregulation of MDR1 gene expression is implicated. In the present study the aim was to assess the involvement of ETS1 and the genes, which encode the proteins interacting with ETS1 in drug resistant MCF-7 breast cancer cells.