Identifying Potential Ageing-Modulating Drugs <i>In Silico</i>
TRENDS IN ENDOCRINOLOGY AND METABOLISM, cilt.30, sa.2, ss.118-131, 2019 (SCI-Expanded, SSCI, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 30 Sayı: 2
- Basım Tarihi: 2019
- Doi Numarası: 10.1016/j.tem.2018.11.005
- Dergi Adı: TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
- Sayfa Sayıları: ss.118-131
- Orta Doğu Teknik Üniversitesi Adresli: Hayır
Özet
Increasing human life expectancy has posed increasing challenges for healthcare systems. As people age, they become more susceptible to chronic diseases, with an increasing burden of multimorbidity, and the associated polypharmacy. Accumulating evidence from work with laboratory animals has shown that ageing is a malleable process that can be ameliorated by genetic and environmental interventions. Drugs that modulate the ageing process may delay or even prevent the incidence of multiple diseases of ageing. To identify novel, anti-ageing drugs, several studies have developed computational drug-repurposing strategies. We review published studies showing the potential of current drugs to modulate ageing. Future studies should integrate current knowledge with multi-omics, health records, and drug safety data to predict drugs that can improve health in late life.