Determination of Phthalates in Milk by Ultrasound-Assisted Dispersive Liquid-Liquid Microextraction and Gas Chromatography-Mass Spectrometry

TUNCEL S. G., Senlik D.

ANALYTICAL LETTERS, vol.49, no.9, pp.1334-1343, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 9
  • Publication Date: 2016
  • Doi Number: 10.1080/00032719.2015.1098654
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1334-1343
  • Keywords: Gas chromatography-mass spectrometry, milk, phthalates, ultrasound-assisted dispersive liquid-liquid microextraction, ESTERS, EXTRACTION
  • Middle East Technical University Affiliated: Yes


Ultrasound-assisted dispersive liquid-liquid microextraction was coupled with gas chromatography-mass spectrometry for the determination of phthalate esters in milk. Dimethyl phthalate, diethyl phthalate, dibutyl phthalate, benzyl butyl phthalate, bis(2-ethylhexyl) phthalate, and dioctyl phthalate were analyzed in five brands of pasteurized Turkish milk. The efficiencies of the extraction procedure for the analytes were between 66 and 100%. The linear dynamic ranges of the calibration curves were from 0.025 to 1.000 mu g/mL with correlation coefficients exceeding 0.99. The precision of the method is acceptable with relative standard deviation values below 5%. Dibutyl phthalate and bis(2-ethylhexyl) phthalate were commonly observed in milk.