Determining the origin of synchronous multifocal bladder cancer by exome sequencing

Acar O., Ozkurt E., Demir G., Sarac H., ALKAN C., Esen T., ...Daha Fazla

BMC CANCER, cilt.15, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1186/s12885-015-1859-8
  • Dergi Adı: BMC CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Multifocal bladder cancer, Next-generation sequencing, Population genetics, APOBEC deaminase, GENETIC-ANALYSIS, MUTAGENESIS, EVOLUTION, CARCINOMA, GENOME, DNA
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Background: Synchronous multifocal tumours are commonly observed in urothelial carcinomas of the bladder. The origin of these physically independent tumours has been proposed to occur by either intraluminal migration (clonal) or spontaneous transformation of multiple cells by carcinogens (field effect). It is unclear which model is correct, with several studies supporting both hypotheses. A potential cause of this uncertainty may be the small number of genetic mutations previously used to quantify the relationship between these tumours.