RBPSponge: genome-wide identification of lncRNAs that sponge RBPs


HafezQorani S., Houdjedj A., Arici M., Said A., KAZAN H.

BIOINFORMATICS, cilt.35, ss.4760-4763, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 35 Konu: 22
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1093/bioinformatics/btz448
  • Dergi Adı: BIOINFORMATICS
  • Sayfa Sayıları: ss.4760-4763

Özet

The Summary: Long non-coding RNAs (lncRNAs) can act as molecular sponge or decoys for an RNA-binding protein (RBP) through their RBP-binding sites, thereby modulating the expression of all target genes of the corresponding RBP of interest. Here, we present a web tool named RBPSponge to explore lncRNAs based on their potential to act as a sponge for an RBP of interest. RBPSponge identifies the occurrences of RBP-binding sites and CLIP peaks on lncRNAs, and enables users to run statistical analyses to investigate the regulatory network between lncRNAs, RBPs and targets of RBPs.