RBPSponge: genome-wide identification of lncRNAs that sponge RBPs

HafezQorani S., Houdjedj A., Arici M., Said A., KAZAN H.

BIOINFORMATICS, cilt.35, sa.22, ss.4760-4763, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 22
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1093/bioinformatics/btz448
  • Dergi Adı: BIOINFORMATICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.4760-4763
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

The Summary: Long non-coding RNAs (lncRNAs) can act as molecular sponge or decoys for an RNA-binding protein (RBP) through their RBP-binding sites, thereby modulating the expression of all target genes of the corresponding RBP of interest. Here, we present a web tool named RBPSponge to explore lncRNAs based on their potential to act as a sponge for an RBP of interest. RBPSponge identifies the occurrences of RBP-binding sites and CLIP peaks on lncRNAs, and enables users to run statistical analyses to investigate the regulatory network between lncRNAs, RBPs and targets of RBPs.