In addition to playing a role in the deterioration of depressed people's interpersonal environment, excessive reassurance-seeking may be implicated as a vulnerability factor for depression. If so, excessive reassurance-seeking should display relative specificity to depression versus other forms of psychopathology. Two studies of psychiatric inpatients (Study 1 on adults and Study 2 on children) tested this possibility. In Study 1 a Depressed group obtained higher reassurance-seeking scores than an Other Disorders group did. Similar findings were obtained in Study 2, such that depressed youth reported higher reassurance-seeking than nondepressed youth. Hence, these two studies of psychiatric inpatients provided reasonable support for the specificity of excessive reassurance-seeking to depression as compared to other forms of psychopathology.