Intramolecular Heterocyclization of O-Propargylated Aromatic Hydroxyaldehydes as an Expedient Route to Substituted Chromenopyridines under Metal-Free Conditions


Keskin S., BALCI M.

ORGANIC LETTERS, cilt.17, ss.964-967, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 17 Konu: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1021/acs.orglett.5b00067
  • Dergi Adı: ORGANIC LETTERS
  • Sayfa Sayısı: ss.964-967

Özet

A concise and regioselective approach to the synthesis of chromenopyridine and chromenopyridinone derivatives was developed. The synthetic strategy relies on the O-propargylation of aromatic hydroxyaldehydes followed by reaction with propargylamine. The intramolecular cycloaddition reaction between the alkyne and azadiene, which is formed as an intermediate, furnished the desired skeletons.