Magnesium doping on TiN coatings affects mesenchymal stem cell differentiation and proliferation positively in a dose-dependent manner


ÖNDER S., Calikoglu-Koyuncu A. C. , Kazmanli K., Urgen M., Kök F. N. , KÖSE G.

BIO-MEDICAL MATERIALS AND ENGINEERING, vol.29, no.4, pp.427-438, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.3233/bme-181000
  • Title of Journal : BIO-MEDICAL MATERIALS AND ENGINEERING
  • Page Numbers: pp.427-438
  • Keywords: Titanium, magnesium, mesenchymal stem cell, differentiation, biomineralization, hard tissue implants, IMPLANTS, BEHAVIOR

Abstract

BACKGROUND: In vitro evaluation of cell-surface interactions for hard tissue implants have mostly been done using osteoblasts. However, when an implant is placed in the body, mesenchymal stem cells (MSCs) play a major role in new bone formation. Therefore, using MSCs in cell-surface investigations may provide more reliable information on the prediction of in vivo behavior of implants.