A new chiral phosphine oxide ligand for enantioselective 1,3-dipolar cycloaddition reactions of azomethine ylides


ERÖKSÜZ S., DOĞAN Ö. , Garner P. P.

TETRAHEDRON-ASYMMETRY, vol.21, no.20, pp.2535-2541, 2010 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 20
  • Publication Date: 2010
  • Doi Number: 10.1016/j.tetasy.2010.10.002
  • Title of Journal : TETRAHEDRON-ASYMMETRY
  • Page Numbers: pp.2535-2541

Abstract

A new set of phosphorus-containing chiral ligands has been synthesized and used with silver(I) for the catalytic asymmetric 1 3-dipolar cycloaddition reaction of azomethine ylides One of these ligands (POFAM6) was found to produce an effective catalyst for the asymmetric 1 3 dipolar cycloaddition reaction of azomethine ylides with electron deficient dipolarophiles to form pyrrolidines in up to 97% yield and 89% (C) 2010 Elsevier Ltd All rights reserved