A CMOS-based highly scalable flexible neural electrode interface

Zhao E. T., Hull J. M., Hemed N. M., Uluşan H., Bartram J., Zhang A., ...Daha Fazla

SCIENCE ADVANCES, cilt.9, sa.23, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 23
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1126/sciadv.adf9524
  • Dergi Adı: SCIENCE ADVANCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, Compendex, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Orta Doğu Teknik Üniversitesi Adresli: Hayır

Özet

Perception, thoughts, and actions are encoded by the coordinated activity of large neuronal populations spread over large areas. However, existing electrophysiological devices are limited by their scalability in capturing this cortex-wide activity. Here, we developed an electrode connector based on an ultra-conformable thin-film electrode array that self-assembles onto silicon microelectrode arrays enabling multithousand channel counts at a millimeter scale. The interconnects are formed using microfabricated electrode pads suspended by thin support arms, termed Flex2Chip. Capillary-assisted assembly drives the pads to deform toward the chip surface, and van der Waals forces maintain this deformation, establishing Ohmic contact. Flex2Chip arrays successfully measured extracellular action potentials ex vivo and resolved micrometer scale seizure propagation trajectories in epileptic mice. We find that seizure dynamics in absence epilepsy in the Scn8a+/- model do not have constant propagation trajectories.